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HOD & Senior Consultant · Surgical Oncology
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Home/PIPAC/Symptoms, Safety & Trials
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PIPAC patient guide

PIPAC Symptom Relief, Safety and Clinical Trials

Questions answered on this page

1. Can PIPAC relieve ascites and abdominal symptoms?

PIPAC may reduce malignant ascites (abdominal fluid), abdominal pain and bloating in some patients, which can contribute to better quality of life.

Reduced need for fluid drainage (paracentesis) has been reported after repeated sessions. Symptom benefit does not occur in everyone, and improvement often builds over several cycles.

2. Is PIPAC safe for medical staff and my family?

PIPAC is performed as a closed-system procedure with remote injection and filtered evacuation, and workplace studies have reported minimal contamination when safety protocols are followed.

Typical safety measures at specialist centers include:

  • Staff leave the room during aerosol delivery.
  • The abdomen is a sealed space, and the aerosol is removed through a closed filter system.
  • Protective clothing and environmental monitoring are used.
  • Available evidence suggests little risk to family members after you return home; follow your hospital’s advice on handling body fluids.

3. Will PIPAC cause hair loss?

Hair loss is generally uncommon with PIPAC because drug doses are low and little enters the bloodstream, although some patients notice thinning, particularly when PIPAC is combined with systemic chemotherapy.

Whether you lose hair depends on the drugs used and any other treatment you receive. Your oncologist can tell you what to expect for your regimen.

4. Can I join a PIPAC clinical trial?

Patients who meet eligibility criteria may be able to join a PIPAC clinical trial, which can provide access to treatment and contributes to the evidence needed to assess its value.

The usual route into a clinical trial follows the steps below:

Table 19: Steps to join a PIPAC clinical trial
StepAction
1Ask your oncologist whether a suitable trial exists
2Search registries such as ClinicalTrials.gov
3Review eligibility, visit schedule, costs and risks
4Discuss with the trial team and give informed consent
Important medical notice. This content is for general education and does not replace advice from your oncologist or surgeon. PIPAC availability, drug regimens, eligibility and evidence differ between countries and centers, and many uses remain investigational. Speak to a qualified multidisciplinary cancer team about your own situation.

Have questions about PIPAC? Talk to a surgical oncologist.

Book a consultation or request a second opinion with Dr Ashwin K.R.