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PIPAC patient guide

PIPAC Procedure, Preparation and Recovery: A Patient Guide

Questions answered on this page

1. What happens during the PIPAC procedure, step by step?

A PIPAC procedure is typically a laparoscopic operation under general anesthesia lasting roughly one to two hours, during which chemotherapy aerosol is delivered into the abdomen for about 30 minutes.

From the patient’s point of view, the day of treatment usually follows this order:

Table 12: PIPAC treatment day: patient timeline
OrderStageWhat you can expect
1AdmissionCheck-in, final questions and consent review
2AnesthesiaGeneral anesthesia is given so you are asleep during the procedure
3ProcedureSmall incisions, inspection, biopsies and aerosol delivery (about 30 minutes of exposure)
4ClosureAerosol is removed, ports are taken out and incisions are closed
5Recovery roomMonitoring as you wake up, with pain and nausea control
6WardGradual eating and walking before discharge, often within 1–3 days

2. How should I prepare for a PIPAC procedure?

Preparation for PIPAC usually includes pre-treatment tests, review of your medications, fasting before anesthesia, and arranging support for the days after treatment.

The checklist below groups preparation tasks by timing; your hospital will give you exact instructions:

Table 14: PIPAC preparation checklist
WhenAction
Weeks beforeComplete blood tests, imaging and an anesthesia assessment
Weeks beforeReview blood thinners, diabetes drugs and supplements with your team
Day beforeFollow any bowel preparation advice you are given
Day of treatmentFollow fasting instructions (often no food for about 6 hours before anesthesia)
Day of treatmentPack for a short stay and arrange transport home
After dischargePlan for help at home for the first few days

3. When can I eat, work and return to normal activities after PIPAC?

Many patients resume light eating within a day and usual activities within one to two weeks, though fatigue and appetite changes can last longer depending on other treatment.

General guidance for returning to daily life is summarized below; follow your own team’s advice:

Table 15: Returning to activities after PIPAC
ActivityGeneral guidance
EatingSmall, frequent meals at first; increase as tolerated
WorkOften possible within one to two weeks for desk-based roles
ExerciseGentle walking is usually encouraged; avoid heavy lifting until cleared
DrivingOnly when pain-free and off strong pain relief

4. What follow-up is needed after PIPAC?

Follow-up after PIPAC generally includes symptom checks, blood tests and scheduled reassessment, with repeat laparoscopy at each cycle and imaging after a course of treatment.

Ask for a written plan at discharge covering who to call, day and night.

Contact your care team urgently, or seek emergency care, if you develop any of the following warning signs:

  • Severe or worsening abdominal pain.
  • Persistent vomiting.
  • Fever.
  • Redness or discharge at a wound.
  • Inability to pass gas or stool.

5. Why might a PIPAC procedure be cancelled or not completed?

A PIPAC procedure may be stopped if the surgeon cannot enter the abdomen safely because of adhesions, or if unexpected findings such as bowel obstruction or extensive disease make treatment unsafe.

Common reasons a procedure may be cancelled or not completed include:

  • Dense adhesions from previous surgery.
  • Findings on laparoscopy that change the treatment plan.
  • Bleeding or bowel injury risk.
  • Anesthesia-related concerns on the day.

Even then, biopsies and information gained may still guide other options.

6. Can I have PIPAC if I have had previous abdominal surgery?

Previous abdominal surgery does not necessarily rule out PIPAC, but scar tissue (adhesions) can make safe laparoscopic entry difficult and is a recognized reason a procedure may not be completed.

Surgeons plan the entry point carefully, sometimes using an open technique at the first port. If the abdomen cannot be entered safely, the procedure is usually stopped and other options are discussed.

Important medical notice. This content is for general education and does not replace advice from your oncologist or surgeon. PIPAC availability, drug regimens, eligibility and evidence differ between countries and centers, and many uses remain investigational. Speak to a qualified multidisciplinary cancer team about your own situation.

Have questions about PIPAC? Talk to a surgical oncologist.

Book a consultation or request a second opinion with Dr Ashwin K.R.